Viagra, Cialis, Levitra or Stendra: which is better?

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The drugs are all PDE5 inhibitors and they all work the same way. They help relax muscles and increase blood flow to the body.

This makes it easier for blood to enter the penis and allows people with erectile dysfunction to have a long-lasting erection during sexual activity.

The drugs work relatively quickly, but the exact timing depends on the drug.

This chart shows when to take the medicine, the usual starting dose in milligrams (mg), and how long the effect is likely to last. Note that a doctor may adjust the dose for people with certain health conditions and those using other medications.

Viagra, Cialis, Levitra and Stendra are all drugs to treat the symptoms of erectile dysfunction.

A doctor will arrive at a diagnosis of erectile dysfunction if a person experiences any of the following criteria:

  • never being able to get an erection
  • often being unable to get an erection
  • being able to get an erection but not lasting long enough for intercourse

Certain aspects of physical and mental health can contribute to erectile dysfunction, and a doctor will discuss these habits and lifestyle with the person before prescribing these medications.

Doctors may not prescribe the drugs to someone who has a cardiovascular condition, which makes sexual activity unsafe for them.

Medications are also not suitable for use with certain medications. Below, learn more about drugs that may interact with these drugs.

Viagra, Cialis, Levitra and Stendra have many similar side effects and interactions, but there are also some variations.

Anyone considering using these medications should consult a doctor first. Medications may not be right for everyone because they may affect a person’s existing health conditions or interact with other medications the person is taking.

None of these medications are suitable for someone who has been advised by a health professional to avoid sexual activity because they have cardiovascular problems or are taking nitrates for heart disease.

Using these drugs with nitrates or alpha-blockers can cause a sudden drop in blood pressure, leading to dizziness, fainting, and possibly falls and injury.

A older study in rodents suggests that the following drugs may increase the concentration of PDE5 inhibitors in the body, and therefore a person should consult a doctor before using ED drugs with any of them:

  • the antibiotics erythromycin and clarithromycin
  • ketoconazole, an antifungal and anti-dandruff agent
  • HIV protease inhibitors, such as ritonavir

Grapefruit juice is a CYP3A4 inhibitor and may increase the impact of these drugs.

The following table compares the possible side effects of the four drugs.

viagra drug interactions

Viagra may interact with the following drugs:

  • nitrates, such as nitroglycerin
  • alpha-blockers
  • drugs to lower blood pressure
  • CYP4 inhibitors, such as ritonavir, ketoconazole, and erythromycin

Cialis interactions and warnings

People should not use Cialis with the following medicines:

  • nitrates
  • alpha-blockers
  • drugs to reduce blood pressure
  • CYP3A4 inhibitors, such as ketoconazole and ritonavir, as they may increase the impact
  • CYP3A4 inducers, such as the antibiotic rifampicin, as these may prevent Cialis from working

Levitra Interactions and Warnings

People should not use Levitra if they have an irregular heartbeat or if they are using the following:

  • nitrates
  • alpha-blockers
  • drugs to lower blood pressure

A doctor may adjust the dose if the person has liver problems or is already using any of the following:

  • ritonavir, indinavir, saquinavir, or atazanavir, which are antiretroviral drugs that doctors use to treat or prevent HIV
  • the antifungal medicines ketoconazole or itraconazole
  • the antibiotics clarithromycin or erythromycin

Stendra Interactions and Warnings

A person should not take Stendra with nitrates or strong CYP3A4 inhibitors, such as ketoconazole or ritonavir.

A doctor can adjust the dose if a person is using alpha blockers or moderate medication. CYP3A4 inhibitorsuch as erythromycin, amprenavir or diltiazem.

People should be careful when using Stendra with the following because they may cause low blood pressure:

  • drugs to reduce blood pressure
  • alcohol
  • alpha-blockers

Other Concerns

Individuals should also ensure that their product is an approved version and follow the advice of a physician when purchasing any of these drugs.

In 2020, for example, the FDA advised people not to buy an imported product sold as a supplement called USA Viagra.

The FDA has warned that this product contains sildenafil but is not an approved form of Viagra and could be dangerous, especially for people with certain health conditions and those taking medications that may interact.

Although these medications can help manage erectile dysfunction, a doctor may recommend trying lifestyle changes before taking medication.

Actions that can help improve ED include:

He is advised for anyone who has concerns about erectile dysfunction to see a doctor as they may be able to help you. For example, they may prescribe one of these drugs.

If a person is already using any of these medications, they should contact a doctor if the medication does not help or if they experience side effects such as vision changes. The doctor may recommend changing the dose or type of medicine.

People should seek immediate medical attention if they experience any of the following:

  • vision loss
  • hearing loss
  • priapism

Viagra, Cialis, Levitra, and Stendra can help a person get an erection, but they won’t cure erectile dysfunction. Other possible treatments include testosterone therapy and, in some cases, surgery.

Below we answer some of the most common questions about Viagra, Cialis, Levitra and Stendra.

Which is better: Viagra, Cialis, Levitra or Stendra?

The choice will depend on the person and various factors, such as whether or not the person has regular sex, other medications they are taking, and the cost and availability of erectile dysfunction medications.

Individuals should consult a medical professional to help them decide.

Do these drugs make you fat?

They don’t. They improve blood flow to the penis during an erection, but they do not change penis size.

Which pill lasts the longest?

The effects of Cialis (tadalafil) last up to 36 hours, but this only means that a person can have one or more erections during this time. This does not mean that they will have an erection lasting 36 hours.

Viagra, Levitra, Cialis and Stendra can help a person with erectile dysfunction achieve and maintain an erection.

There are many side effects and interactions to consider. However, studies show that with the right choice and correct use, these drugs can help a person overcome erectile dysfunction and engage in sexual activity.

It should be noted that none of these drugs will provide sexual stimulation. The person will need stimulation to get an erection.

The only way to decide on the best drug may be through trial and error. Working directly with a doctor can help a person track side effects and decide which medication is best for them.

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