Verquvo (Vericiguat) Oral: Uses, Side Effects, Dosages

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What is Verquvo?

Verquvo (vericiguat) is an oral prescription drug used to reduce the risk of death and the need for hospitalization in some people with heart failure. Verquvo belongs to a group of medicines called soluble guanylate cyclase (sGC) stimulators. It works by relaxing smooth muscles and widening blood vessels (vasodilation), making it easier for the heart to pump blood and oxygen throughout the body.

Medication Facts

Generic name: Vericiguat

brand names): Verquvo

Administrative road(s): Oral

Availability of drugs: Prescription

Therapeutic classification: Soluble guanylate cyclase stimulator

Available generically: Nope

Controlled substance: N / A

active ingredient: Vericiguat

Dosage form(s): Tablet

What is Verquvo used for?

The Food and Drug Administration (FDA) has approved Verquvo to reduce the risk of death or the need for hospitalization in certain people with heart failure. Verquvo may be right for you if:

  • You have chronic (long-standing) heart failure and have symptoms
  • You have an ejection fraction (the amount of blood pumped with each heartbeat) of less than 45%
  • You have been hospitalized for heart failure or received IV (intravenous) medication to help control your symptoms

How to take Verquvo

Verquvo comes as an oral tablet to be taken once daily with food. Your healthcare provider may slowly increase your dose every two weeks to find the best dose for you.

The FDA has issued a boxed warning (the agency’s strongest warning) for Verquvo due to its potential to cause birth defects if taken during pregnancy. For this reason, people who could become pregnant should use an effective form of contraception while taking Verquvo and for one month after stopping treatment. Your healthcare provider will ask you to take a pregnancy test before starting Verquvo to make sure you are not pregnant.

Storage

Store Verquvo at room temperature. Be sure to store Verquvo and all your medicines in a safe place that is high up and out of the reach of children and pets.

What are the side effects of Verquvo?

This is not a complete list of side effects and others may occur. A health care provider can advise you about side effects. If you experience any other effects, contact your pharmacist or healthcare provider. You can report side effects to the FDA at fda.gov/medwatch or 1-800-FDA-1088.

Common side effects

Verquvo is generally well tolerated, but side effects may occur. Be sure to tell your healthcare provider if you experience any side effects that bother you or don’t go away. Common side effects include:

Serious side effects

Rarely, Verquvo can cause serious side effects. Tell your health care provider if you experience any of the following symptoms. This could mean that your red blood cell count is very low.

  • Fatigue
  • Shortness of breath
  • Pale skin

Report side effects

This is not a complete list of side effects and others may occur. A health care provider can advise you about side effects. If you experience any other effects, contact your pharmacist or healthcare provider. You can report side effects to the FDA at fda.gov/medwatch or 1-800-FDA-1088.

Dosage: How much Verquvo should I take?

Contents of the drug supplied and reviewed by

IBM Micromedex®

The dose of this drug will be different for different patients. Follow your doctor’s orders or label directions. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you.

The amount of medicine you take depends on the strength of the medicine. Also, the number of doses you take each day, the time between doses, and how long you take the medicine depends on the medical condition for which you are using the medicine.

  • For oral dosage form (tablets):

    • For chronic heart failure:

      • Adults—Initially, 2.5 milligrams (mg) once daily. Your doctor may adjust your dose based on need and tolerance. However, the dose is usually no more than 10 mg once a day.
      • Children—Use and dose should be determined by your doctor.

Amendments

If you have trouble swallowing tablets, you can crush the Verquvo tablets and mix them with water. Be sure to swallow the mixture immediately – don’t save it for later.

Missed dose

If you miss a dose of Verquvo, take it as soon as you remember, as long as it’s the same day. If you don’t remember until the next day, skip the missed dose and go back to your usual dosing schedule. Do not double up or take extra Verquvo.

Overdose: What happens if I take too much Verquvo?

Taking too much Verquvo can cause your blood pressure to drop, making you feel dizzy and lightheaded. It is important to take only the prescribed dose of Verquvo. Ask your healthcare professional or pharmacist if you are unsure how much to take.

What happens if I overdose on Verquvo?

If you think you or anyone else may have overdosed Verquvo, call a healthcare provider or the Poison Control Center (800-222-1222).

If someone collapses or is not breathing after taking Verquvo, call 911 immediately.

Precautions

Contents of the drug supplied and reviewed by

IBM Micromedex®

It is very important that your doctor checks your progress at regular visits to make sure this medicine is working properly and to check for side effects. Blood tests may be needed to check for side effects.

Using this medication while you are pregnant may harm your unborn baby. If you are a woman who could become pregnant, your doctor may carry out tests to ensure that you are not pregnant before starting treatment. Use an effective form of birth control to avoid becoming pregnant while using this medicine and for at least 1 month after your last dose. Tell your doctor immediately if you think you might be pregnant.

Do not use this medication with any other soluble guanylate cyclase (sGC) stimulator. Do not use this medicine with a medicine to treat erectile dysfunction (eg, sildenafil). Using these medicines together may cause hypotension (low blood pressure).

What are the reasons why I should not take Verquvo?

Certain conditions increase your risk of developing complications from Verquvo. Do not take Verquvo if you:

  • Take other sGC stimulators, such as Adempas (riociguat)
  • are pregnant, plan to become pregnant, or are breastfeeding

Tell your healthcare provider about all of your medical conditions to decide if Verquvo is a safe treatment option for you.

What other medicines interact with Verquvo?

Some medicines can interact with Verquvo and affect how it works. Be sure to tell your health care provider about all medications you take, including over-the-counter and non-prescription products.

You should not take other sGC stimulators (eg, riociguat) with Verquvo, as this may increase your risk of side effects.

Phosphodiesterase-5 (PDE-5) inhibitors may increase your risk of low blood pressure when taken with Verquvo. PDE-5 inhibitors, commonly used to treat erectile dysfunction and pulmonary hypertension, include:

This is not a complete list of all drugs that may interact with Verquvo. Always keep an up-to-date list of all the medications you take and let your healthcare professional and pharmacist know if there are any changes.

Frequently Asked Questions

  • What is Verquvo used for?

    Verquvo is used to reduce the risk of death or the need for hospitalization due to complications from heart failure. Your healthcare provider may prescribe Verquvo to treat your heart failure if you have recently been hospitalized or received IV medications to control your symptoms.

  • How does Verquvo work?

    Verquvo works by relaxing and widening blood vessels. This decreases how hard the heart has to work to pump blood and oxygen throughout the body.

  • What medicines should not be taken with Verquvo?

    You should not take other sGC stimulators or PDE-5 inhibitors (medicines commonly used to treat erectile dysfunction and pulmonary hypertension) with Verquvo. These include Stendra (avanafil), Revatio, Viagra (sildenafil), Adcirca, Cialis (tadalafil), vardenafil and Adempas (riociguat).

  • What are the side effects of Verquvo?

    The most common side effects of Verquvo include low blood pressure and low red blood cell count (anemia). Tell your healthcare provider if you feel lightheaded or lightheaded while taking Verquvo.

How can I stay healthy while taking Verquvo?

If you are having trouble controlling your heart failure, your healthcare provider can add Verquvo to your treatment plan. Verquvo needs food to help your body absorb it, so be sure to take your dose with a meal.

Since Verquvo can cause fetal harm, you should make sure you are not pregnant before starting treatment. Talk to your healthcare provider about your birth control options. You must use effective contraception during treatment and for one month after stopping Verquvo.

Medical Disclaimer

Verywell Health medication information is for educational purposes only and is not intended to replace medical advice, diagnosis, or treatment from a healthcare provider. Consult your health care provider before taking any new medications. IBM Watson Micromedex provides some of the drug content as listed on the page.

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