Alzheimer’s Q&A: Sildenafil Has Potential as an Alzheimer’s Drug | Entertainment/Life


Is sildenafil considered a potential treatment for Alzheimer’s disease?

Sildenafil could potentially be used as a treatment for Alzheimer’s disease, according to findings recently published in Nature Aging by Feixong Cheng of the Cleveland Clinic.

According to MedlinePlus, an online information service produced by the US National Library of Medicine, sildenafil is a common prescription drug sold as Viagra to treat erectile dysfunction and as Revatio to improve the ability to exercise in adults with pulmonary hypertension, which is high blood pressure. in the vessels carrying blood to the lungs, causing shortness of breath, dizziness and fatigue.

“Notably, we found that sildenafil use reduced the likelihood of Alzheimer’s disease in people with coronary heart disease, hypertension, and type 2 diabetes, all of which are comorbidities significantly associated with disease risk. , as well as those who don’t,” Cheng said. “Sildenafil, which has been shown to significantly improve cognition and memory in preclinical models, is being touted as the best drug candidate.”

Researchers have been looking for drugs that target amyloid plaques and tau tangles, hallmarks of brain damage associated with Alzheimer’s disease. Instead of targeting amyloid or tau alone, researchers have narrowed their scope even further to identify therapies that attack both molecules at the same time.

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In the study, researchers used a database of health insurance claims for more than 7 million people in the United States to understand the relationship between sildenafil and Alzheimer’s disease outcomes.

They compared sildenafil users to non-users and found that those using the drug were 69% less likely to have the wasting brain disorder, even after six years of follow-up.

Although the study established a link between sildenafil and reduced risk of Alzheimer’s disease and offered a new avenue of study in this area, the researchers pointed out that the investigation did not prove that the drug actually offered protection or benefit in this regard.

Cheng cautiously noted that the study does not demonstrate a fortuitous relationship between the drug and Alzheimer’s disease and that researchers need to conduct more placebo-controlled clinical trials to determine the drug’s effectiveness.

Doctors probably won’t recommend using sildenafil as a treatment yet. After reviewing the study, Susan Kohlhaas, Director of Research at Alzheimer’s Research UK, noted: “Being able to reuse an already approved drug for health problems could help speed up the drug discovery process and provide more life-changing dementia treatments early. This research does not prove that sildenafil is responsible for reducing the risk of dementia, or that it slows or stops the disease. The first port of call is to talk to your doctor.

Questions about Alzheimer’s disease or related disorders can be sent to Dana Territo, author of the upcoming book “What My Grandkids Taught Me About Alzheimer’s Disease”, at [email protected]


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